There is a large body of anecdotal evidence that clearly shows that microdosing leads to physical, mental, and emotional improvement. Dr. James Fadiman, a well-respected transpersonal psychologist, has been collecting reports on microdosing from people around the world since the 1960s. It comes as no surprise that he is often referred to as “The Father of Microdosing”.
What we do know is that psychedelic substances act on the serotonin (5-HT) receptors in our brains. Serotonin is a chemical messenger or neurotransmitter that delivers messages between nerve cells in the brain and throughout the body. These messages mediate satisfaction, happiness, and optimism. Serotonin levels are reduced in depression, and most modern anti-depressant drugs, known as serotonin reuptake inhibitors (SSRIs), act by increasing the amount of serotonin available to brain cells.
Serotonin receptors are found throughout our nervous system and govern many aspects of our being, including mood, thinking, and sexual desire. Psychedelics bind most effectively to the 5HT-2A receptor, which is one of the receptors involved in learning, memory, and cognition. As a result, when consuming only a microdose of a psychedelic substance and thus avoiding the “classical trip,” the brain can focus solely on the cognitive boost caused by these receptors.
Microdosing is a practice that yields the best results when it’s done over an extended period of time following a dosing scheme or protocol. The exact effects and results of this practice depend greatly on the person, the substance, the dosage, and many other personal factors such as one’s intention, expectations, and mindset.